The 2019 coronavirus pandemic (COVID-19) is having a catastrophic impact on the health of humanity. The widespread community transmission has caused the corresponding authorities to implement strict distancing measures with severe economic consequences.
The control of the virus will depend on the transmission chains' interruption until the protective herd immunity generated by the vaccine or acquired naturally arises.
However, approved antiviral treatments such as Remdesivir, convalescent serum, and monoclonal antibodies can only be administered intravenously, making them poorly suited for transmission control.
Advances in the studies of the drug Molnupiravir MK-4482 / EIDD-2801 are encouraging as it is a therapeutic option that is administered orally and appears to eliminate the virus in 24 to 48 hours.
Previously, the journal Nature revealed its research on developing an orally effective ribonucleoside analog inhibitor MK-4482 / EIDD-2801 of influenza viruses that were used for use against severe acute respiratory syndrome coronavirus 2 (SARS). -CoV-2) and is currently in phase II / III clinical trials (NCT04405570 and NCT04405739).
The investigation "Therapeutically administered ribonucleoside analog MK-4482 / EIDD-2801 blocks transmission of SARS-CoV-2 in ferrets" was conducted by the Institute of Biomedical Sciences at Georgia State University.
This research examines the efficacy of MK-4482 / EIDD-2801, also known as Molnupiravir, which was administered therapeutically in ferrets to mitigate the infection caused by the SARS-CoV-2 virus and block the transmission of the COVID disease. -19.
During the investigation, Therapeutic treatment administered MK-4482 / EIDD-2801 in mitigating SARS-CoV-2 infection and blocking transmission in the ferret model was examined since ferrets, and related members of the genus weasel transmit the virus efficiently with a clinical minimum, which resembles the spread in the young adult human population.
A high burden of SARS-CoV-2 in nasal tissues and secretions was confirmed, which coincided with efficient transmission through direct contact. Therapeutic treatment of animals infected with MK-4482 / EIDD-2801 twice daily significantly reduced the burden of SARS-CoV-2 in the upper respiratory tract and completely abolished the spread to untreated contact animals. This study identified oral MK-4482 / EIDD-2801 as a promising antiviral.
If the Molnupiravir MK-4482 / EIDD-2801 medicine is available, we will communicate it promptly.
Measures to avoid getting infected
It is important to know the risks and how to protect yourself as much as possible. People most at risk for seriously COVID-19 should consider their level of risk before going out and take the necessary steps to protect themselves.
Use of mask
Handwashing with gels or hand solutions with at least 60% alcohol, if possible
Avoid having contact with people who do not wear masks or ask those around you to wear masks
Avoid closed spaces, poorly ventilated or with a large influx of people
BlueNetHospitals is a safe and COVID-19 Free hospital. Your well-being and safety are our priority.
And remember: Get tested!
Where can I get a test for COVID-19 in Los Cabos? Visit ourlink to find more information about it.
Why is COVID-19 testing important? COVID-19 testing will help you protect your family, your community, and yourself.
It will save lives!
BlueNetHospitals - Hospital Los Cabos
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